NN106 Cyto-C

Welcome to the home on NeuroNEXT protocol NN 106 – CYTO-C (Cytochrome C Oxidase Activity in Newly Diagnosed GBM).

Glioblastoma multiforme is the most common malignant primary brain tumor. These tumors are often aggressive and infiltrate surrounding brain tissue. Signs and symptoms are initially non-specific. They may include headaches, personality changes, nausea, and symptoms similar to that of a stroke. Worsening of symptoms is often rapid and can progress to unconsciousness.

This research study is being conducted to prospectively evaluate the hypothesis that the overall survival time of a subject with newly diagnosed GBM tumors, treated with standard of care therapy, is a function of the CcO enzymatic activity in the tumor. In particular, tumors with high CcO activity, are associated with shorter time of overall survival when compared to tumors with low CcO activity. Standard of care therapy consists of post-surgical radiation therapy with concurrent Temozolomide followed by up to 12 cycles of adjuvant Temozolomide.

This study is being conducted through the NeuroNEXT Network under a Cooperative Agreement with the National Institute of Neurological Diseases and Stroke (NINDS).


The following institutions are participating in this study:

    • University of Alabama at Birmingham – Birmingham, AL
    • University of Utah – Salt Lake City, UT
    • Swedish Medical Center – Seattle, WA
    • Oregon Health and Science University – Portland, OR
    • University of California-Davis – Davis, CA
    • University of Miami School of Medicine – Miami, FL
    • Vanderbilt University – Nashville, TN
    • University of Texas Southwestern Medical Center – Dallas, TX
    • University of Kansas Medical Center – Kansas City, KS
    • Washington University in St. Louis School of Medicine – St. Louis, MO
    • Northwestern University Feinberg School of Medicine – Chicago, IL
    •  University of Cincinnati – Cincinnati, OH
    • The Ohio State University Medical Center – Columbus, OH
    • University of Pittsburgh – Pittsburgh, PA
    • SUNY Stony Brook University Medical Center – Stony Brook, NY
    • Montefiore Medical Center (Albert Einstein/Yeshiva University – Bronx, NY
    • Columbia University Medical Center – New York, NY
    • Massachusetts General Hospital – Boston, MA
    • University of Rochester Medical Center – Rochester, NY