NN103 - Beat MG

 

 

B Cell Targeted Treatment In Myasthenia Gravis: A Phase II Trial of Rituximab In Myasthenia Gravis        

 

Richard J. Nowak, MD, MS, is the Protocol Principal Investigator for the study “A Phase II Trial of Rituximab in Myasthenia Gravis”.

Myasthenia gravis (MG) is an autoimmune disorder of neuromuscular transmission with an estimated annual incidence of about 1-2 per 100,000 and prevalence as high as 20-50 per 100,000.  Common symptoms include a drooping eyelid, double vision, slurred speech, difficulty chewing and swallowing, weakness in the arms and legs, chronic muscle fatigue, and difficulty breathing.  Despite current therapies a subset of patients remain medically refractory or have intolerable medication adverse effects.  There is need for another agent in the management of MG as there are few effective drugs.  Safe, well-tolerated, effective and steroid-sparing therapeutics are very desirable. 

The purpose of the study is to find out the effect and safety of a new use of the drug rituximab in myasthenia gravis (MG) patients who are on prednisone.  The study intervention is provided by Genentech Pharmaceuticals.

Please see additional detailed study information here: 

For more information about participating, please contact: MGstudy@yale.edu, or call 1-844-MGSTUDY (647-8839)

 

The following twenty six institutions are now open to enrollment.  

Northeast:

  • Yale University - New Haven, CT
    • Principal Investigator: Richard Nowak, MD
    • Coordinator: Joan Nye
    • Telephone: 203-737-7095
    • Email contact: joan.nye@yale.edu

 

  • Albert Einstein College of Medicine Yeshiva University: Montefiore Medical Center - Bronx, NY

 

  • Brigham and Women's Hospital - Boston, MA
    • Principal Investigator: Anthony Amato, MD
    • Coordinator: Kristen Roe
    • Telephone: 617-525-6763
    • Email contact: kroe@partners.org

 

  • New York Presbyterian Hospital - White Plains, NY
    • Principal Investigator: Thomas Brannagan, MD
    • Coordinator: Jacqueline Scoon
    • Telephone: 212-305-6035
    • Email contact: js4462@cumc.columbia.edu

 

  • SUNY Stony Brook University Medical Center - Stony Brook, NY

 

  • SUNY Downstate Medical Center - Brooklyn, NY
    • Principal Investigator: Yaacov Anziska, MD
    • Coordinator: Nadege Gilles, MPH
    • Telephone: 718-270-7786
    • Email contact: nadege.gilles@downstate.edu

 

  • SUNY Buffalo General Hospital - Buffalo, NY
    • Principal Investigator: Gil Wolfe, MD
    • Coordinator: Kara Patrick
    • Telephone: 716-859-7510
    • Email contact: kpatrick@buffalo.edu

 

  • Weill Cornell Medical Center - New York, NY
    • Principal Investigator: Jonathan M. Goldstein, MD
    • Coordinator: Lindsay Kaplan
    • Telephone: 646-797-8657
    • Email contact: KaplanL@HSS.EDU

 

  • University of Pittsburgh - Pittsburgh, PA
    • Principal Investigator: Araya Puwanant, MD
    • Coordinator: Gabriela Niizawa
    • Telephone: 412-383-9775
    • Email contact: niizawaga@upmc.edu

 

  • University of Rochester - Rochester, NY

Midwest:

  • Barnes Jewish Hospital - St. Louis, MO
    • Principal Investigator: Muhammad Al'Lozi, MD
    • Coordinator: Linda Schimmoeller
    • Telephone: 314-747-8288
    • Email contact: schimmoellerl@neuro.wustl.edu

 

  • Northwestern Memorial Hospital - Chicago, IL

 

  • Ohio State University - Columbus, OH
    • Principal Investigator: John T. Kissel, MD
    • Coordinator: Amy Bartlett
    • Telephone: 614-366-9050
    • Email contact: Amy.Bartlett@osumc.edu

 

  • University of Cincinnati - Cincinnati, OH
    • Principal Investigator: Laura Ann Sams, MD
    • Coordinator: Linda Lovell-Ewen
    • Telephone: 513-558-5023
    • Email contact: lovellll@ucmail.uc.edu

 

  • University of Kansas Medical Center - Kansas City, KS
    • Principal Investigator: Mazen Dimachkie, MD
    • Coordinator: Tina Liu
    • Telephone: 913-945-9932
    • Email contact: tliu@kumc.edu

South:

  • University of Alabama at Birmingham - Birmingham, AL
    • Principal Investigator: Mohammad Alsharabati, MD
    • Coordinator: Melanie Benge
    • Telephone: 205-975-0445
    • Email contact: mabenge@uab.edu

 

  • Emory University - Atlanta, GA
    • Principal Investigator: Vita Kesner, MD
    • Coordinator: Elaine Sperin
    • Telephone: 404-712-7044
    • Email contact: esperin@emory.edu

 

  • University of Miami School of Medicine - Miami, FL
    • Principal Investigator: Michael Benatar, MD, MBChB, DPhil
    • Coordinator: Alexandra Waltz
    • Telephone: 305-243-3799
    • Email contact: awaltz@med.miami.edu

 

  • University of Texas Southwestern Medical Center - Dallas, TX

 

  • University of Virginia - Charlottesville, VA
    • Principal Investigator: Ted Michael Burns, MD
    • Coordinator: Stephanie Lowenhaupt
    • Telephone: 434-982-6961
    • Email contact: sal3q@virginia.edu

West:

  • Oregon Health and Science University - Portland, OR
    • Principal Investigator: Vijayshree Yadav
    • Coordinator: Diana Dimitrova
    • Telephone: 503-494-7269
    • Email contact: dimitrov@ohsu.edu

 

  • Swedish Health Services/Swedish Medical Center - Seattle, WA
    • Principal Investigator: Eric Gierke, MD
    • Coordinator: Becky Wood
    • Telephone: 206-320-7115
    • Email contact: becky.wood@swedish.org

 

  • University of California - Davis - Davis, CA
    • Principal Investigator: David P. Richman, MD
    • Coordinator: Randev Sandhu
    • Telephone: 916-734-4303
    • Email contact: rssandhu@ucdavis.edu

 

  • University of California - Los Angeles - Los Angeles, CA
    • Principal Investigator: Perry B. Shieh, MD, PhD
    • Coordinator: Katrina Nguyen
    • Telephone: 310-206-9089
    • Email contact: katrinanguyen@mednet.ucla.edu

 

  • University of Colorado Denver - Denver, CO
    • Principal Investigator: Dianna Quan, MD
    • Coordinator: Ildiko Torok
    • Telephone: 303-724-3736
    • Email contact: ILDIKO.TOROK@ucdenver.edu

 

  • University of Utah - Salt Lake City, UT
    • Principal Investigator: A. Gordon Smith, MD
    • Coordinator: Amanda Emett
    • Telephone: 801-585-2772
    • Email contact: Amanda.emett@hsc.utah.edu